Pd-catalyzed enantioselective C–H arylation of phosphinamides with boronic acids for the synthesis of P-stereogenic compounds
| Autor: | Yuan-Hui Chen, Jing Guan, Fu-She Han, Zhijun Du, Xu-Long Qin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Aryl Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Stereocenter Amino acid Inorganic Chemistry chemistry.chemical_compound Yield (chemistry) Organic chemistry Physical and Theoretical Chemistry |
| Zdroj: | Tetrahedron: Asymmetry. 28:522-531 |
| ISSN: | 0957-4166 |
| DOI: | 10.1016/j.tetasy.2017.03.008 |
| Popis: | A Pd-catalyzed enantioselective C–H arylation of phosphinamides with aryl boronic acids is presented. With readily affordable amino acid derivatives as chiral ligands, the reaction proceeded efficiently to afford the P-stereogenic phosphinamides in up to 75% yield and with 99% ee under mild conditions. Most importantly, the reaction could be performed on a large scale for various substrates. This method provides an alternative and reliable way for accessing P-stereogenic phosphinamides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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