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Background: The coronavirus disease 2019 (COVID-19) has continued to spread across the world with increasing number of confirmed cases and death. Preventive measures have still been the only way of slowing down the transmission and prevention of the deadly disease. Practice of preventive guidelines and perception about the disease is important in this regard. We aimed to study on practice to prevent and perception toward COVID-19 among Bangladeshi adults during the rapid rise of the outbreak.Methods: For this cross-sectional study, we conducted an online survey to collect data from 320 Bangladeshi adults during the period of 10-20 April, 2020 with a self-developed questionnaire. For measuring their level of practice, a general question was asked to participants, “Are you properly following the guidelines recommended by WHO to avoid COVID-19? Four type of perceptions; (i) seriousness, (ii) susceptibility, (iii) efficacy, and (iv) carry out the measures of the disease were considered for measuring risk of perception. Frequency distribution, Chi-square (χ2) test and binary logistic regression model were utilized in this study. Results: More than 71% of participants had good practice of always following the guidelines of the World Health Organization to prevent COVID-19. Logistic regression model demonstrated that people living in urban area (pConclusions: The good practice of preventive guidelines and risk perception toward COVID-19 among Bangladeshi adults were satisfactory but not of the expected level. High socioeconomic status and education were significantly correlated with appropriate practice and perception during the peak time of the COVID-19 pandemic. Government should take step to increase the level of practice to avoid and perception toward COVID-19 among Bangladeshi people during the pandemic. |