Autor:	Matthias J. Merkel, Edward A. Kahl, Michael P. Hutchens
Rok vydání:	2015
Předmět:	Bupivacaine chemistry.chemical_classification CYP2D6 Cytochrome biology Chemistry Pharmacology Non-competitive inhibition Enzyme Pharmacokinetics medicine biology.protein Dexmedetomidine Pharmacokinetic interaction medicine.drug
Zdroj:	A Case Approach to Perioperative Drug-Drug Interactions ISBN: 9781461474944
DOI:	10.1007/978-1-4614-7495-1_35
Popis:	This case discusses a possible pharmacokinetic interaction between bupivacaine and dexmedetomidine. Bupivacaine is a cytochrome P450 2D6 and cytochrome 3A4 substrate. Dexmedetomidine has been shown, in vitro, to inhibit both enzymes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b64b9571b3a45c7612fd57360714530 https://doi.org/10.1007/978-1-4614-7495-1_35 Zobrazit plný text záznamu