C–C Bond Cleavage Initiated Cascade Reaction of β-Enaminones: One-Pot Synthesis of 5-Hydroxy-1H-pyrrol-2(5H)-ones

Autor:	Ting Chen, Xiujuan Zheng, Jinhai Shen, Wenhua Wang, Yanyun Wang, Yadong Feng
Rok vydání:	2021
Předmět:	Hydroxylation chemistry.chemical_compound Cascade reaction Chemistry Stereochemistry Organic Chemistry One-pot synthesis Functional group Bond cleavage
Zdroj:	The Journal of Organic Chemistry. 86:2917-2928
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c02832
Popis:	An unprecedented C(CO)-C(Ar) bond cleavage of β-enaminones has been realized under mild and transition-metal-free conditions. The cascade transformation based on this C-C bond cleavage involves 1,3-O/C migration and aerobic hydroxylation and leads to various 5-hydroxy-1H-pyrrol-2(5H)-ones with broad functional group tolerance. The application of this methodology has been showcased by preparing 5-alkoxy-1H-pyrrol-2(5H)-one derivatives and a pyrrolo[2,1-a]isoquinolin-3-one derivative.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b54e7200d7230bcaab2d6cee738f9e1 https://doi.org/10.1021/acs.joc.0c02832 Zobrazit plný text záznamu