| Autor: |
E.E. Gabbe, K. Kugler, H.C. Heinrich |
| Rok vydání: |
1971 |
| Předmět: |
|
| Zdroj: |
Biochemical Medicine. 5:472-482 |
| ISSN: |
0006-2944 |
| Popis: |
The intestinal 59 Fe absorption from 10-μmole (=0.56 mg) 59 Fe 2+ and hemoglobin- 59 Fe as well as from 5.0-mg hemoglobin- 59 Fe doses was measured with the 59 Fe-absorption whole-body retention test in normal volunteers and in vitamin-B 12 -treated pernicious anemia patients with gastric atrophy and absolute intrinsic-factor deficiency. A completely normal 59 Fe absorption from ferrous iron and hemoglobin iron at the 0.56-mg iron level was observed in all the patients without gastric juice. At the 5.0-mg iron dose level hemoglobin- 59 Fe was even better (2-fold) absorbed in patients with absolute intrinsic-factor deficiency and a purified hog intrinsic-factor concentrate of known potency did not influence the already doubled hemoglobin- 59 Fe absorption. Depleted iron stores in prelatent iron deficiency resulted in a 4-fold increase of 59 Fe 2+ absorption and a 50% increase of hemoglobin- 59 Fe absorption also in patients without gastric juice and without intrinsic factor. Gastric juice or a gastric intrinsic factor are therefore not required for intestinal ferrous iron or hemoglobin-iron absorption in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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