Serum Thyroid Peroxidase Autoantibodies, Thyroid Volume, and Outcome in Breast Carcinoma1
| Autor: | N. J. O’Higgins, M. J. Murray, P. P. A. Smyth, Enda W. McDermott, Mark Kilbane, S.G. Shering, D. F. Smith |
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| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty biology business.industry Endocrinology Diabetes and Metabolism Thyroid disease Biochemistry (medical) Clinical Biochemistry Thyroid Mammary gland medicine.disease Biochemistry Endocrinology medicine.anatomical_structure Thyroid peroxidase Internal medicine medicine Carcinoma biology.protein Breast disease skin and connective tissue diseases Breast carcinoma business Survival analysis |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 83:2711-2716 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.83.8.5049 |
| Popis: | The prevalence of thyroid peroxidase autoantibodies (TPO.Ab) was assessed in patients with either breast carcinoma or benign breast disease, and its association with disease outcome in breast carcinoma was studied. TPO.Ab were detected by direct RIA in serum from 121/356 (34.0%) of patients with breast carcinoma, compared with 36/194 (18.5%) of controls (P or = 0.3 U/mL were associated with a significantly better disease-free [relative risk (RR) = 1.84, P 18.8 mL. Multivariate survival analysis showed that both TPO.Ab and thyroid volume were independently associated with prognosis in breast carcinoma and that RRs for disease-free survival were of a similar order of magnitude to well-established prognostic indices such as axillary nodal status or tumor size. These findings supply evidence that manifestations of thyroid autoimmunity are associated with a beneficial effect on disease outcome in breast carcinoma and provide the strongest evidence to date of a biological link between breast carcinoma and thyroid disease. |
| Databáze: | OpenAIRE |
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