Evaluation of a Novel Multi-slit Collimated Detection System for Prompt Gamma-Ray Imaging During Proton Beam Therapy
Autor: | J Ready, Kai Vetter, Lucian Mihailescu, Rebecca W. Pak, Andrew Haefner, V. Negut, J. Ellin |
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Rok vydání: | 2018 |
Předmět: |
Range (particle radiation)
Materials science Proton business.industry Detector Gamma ray Collimator Bragg peak Collimated light 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences 0302 clinical medicine Optics law 030220 oncology & carcinogenesis business Proton therapy |
Zdroj: | 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference Proceedings (NSS/MIC). |
Popis: | Range uncertainty in proton therapy has a significant impact on the utilization and efficacy of the treatment modality. Several methods are under investigation to verify proton range by the detection of secondary emissions, with many studies focused on the use of prompt gamma-ray imaging (PGI) as a means to determine the Bragg peak location. This work introduces a new system and method of PGI using a multi-knife-edge slit collimator and detector. Initial measurements using 50 MeV protons demonstrated the ability of the system to provide 2-dimensional prompt gamma-ray (PG) distributions. A Bragg peak localization precision of 1 mm (2σ) was achieved with delivery of (1.7 ± 0.8) x 108 protons into a PMMA target from an 8 cm standoff distance, suggesting the ability of the system to detect relative shifts in proton range while delivering fewer protons than used in a typical treatment fraction. Additionally, the absolute position of the Bragg peak was identified to within 1.6 mm (2σ) with 5.6 x 1010 protons delivered. The initial results are promising and warrant further investigation and system optimization for clinical implementation. |
Databáze: | OpenAIRE |
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