Mikrobielle Antibiotikafabriken verstehen und verbessern

Autor: Markus Gressler, Hajo Kries
Rok vydání: 2022
Předmět:
Zdroj: BIOspektrum. 28:481-483
ISSN: 1868-6249
0947-0867
DOI: 10.1007/s12268-022-1810-x
Popis: Repurposing the enzymes in microbial metabolism such as nonribosomal peptide synthetases (NRPSs) is explored as a route towards better antibiotics. NRPSs are gigantic enzymatic assembly lines that form highly modified peptides from diverse building blocks. A novel hydroxamate assay detects full substrate profiles of NRPSs from cell-like substrate mixtures. Facile recording of substrate profiles has applications in natural product discovery and engineering.
Databáze: OpenAIRE
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