Coaxial Nanofibrous Scaffold Prepared Using Centrifugal Spinning as a Drug Delivery System for Skeletal Tissue Engineering
| Autor: | Evzen Amler, Michala Rampichová, Vera Lukasova, Eva Filová, Matej Buzgo, Karolina Vocetkova, Veronika Hefka Blahnová, Vera Sovkova |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Chemistry Mechanical Engineering 02 engineering and technology 021001 nanoscience & nanotechnology Skeletal tissue 03 medical and health sciences Mechanics of Materials Drug delivery General Materials Science Nanofibrous scaffold Coaxial 0210 nano-technology Spinning 030304 developmental biology Biomedical engineering |
| Zdroj: | Key Engineering Materials. 834:162-168 |
| ISSN: | 1662-9795 |
| Popis: | Skeletal disorders, caused by trauma, disease, or carcinoma, may result in tissue loss and, finally, in endoprosthesis. Tissue engineering offers an alternative - tissue scaffolds. Its constructs may be seeded with autologous cells or, alternatively, attract cells from the surrounding tissues. Such a scaffold must meet several requirements, such as biocompatibility, biodegradability and suitable morphology for cell attachment and proliferation. Nonetheless, scaffold should stimulate cells migrated from the surrounding tissues to infiltrate the scaffold, proliferate and differentiate to the required cell type. In the current study, we developed a fibrous scaffold with 3D structure using emulsion centrifugal spinning. The scaffold from poly-ɛ-caprolactone contained a cocktail of growth factors, i.e. TGF-β, IGF and bFGF. The released growth factors enhanced cell proliferation and chondrogenic differentiation. The scaffold is a promising material for skeletal tissue engineering. |
| Databáze: | OpenAIRE |
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