Direct, regioselective synthesis of 2,2-dimethyl-2H-chromenes. Total syntheses of octandrenolone and precocenes I and II

Autor:	Steven W. Baldwin, Marc J. Adler
Rok vydání:	2009
Předmět:	Octandrenolone chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Microwave irradiation Regioselectivity Phenol Single step Biochemistry Combinatorial chemistry Catalysis
Zdroj:	Tetrahedron Letters. 50:5075-5079
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.06.090
Popis:	Herein is reported an efficient method for the synthesis of 2,2-dimethyl-2H-chromenes in a single step from the corresponding phenol and 3-methyl-2-butenal via microwave irradiation in CDCl3. This protocol features a mild reaction environment (neutral, no added catalyst) which yields regioselective formation of the chromene and displays tolerance toward acid- and base-sensitive protecting groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b265a3c59da33fab8d2d6d246ebe378 https://doi.org/10.1016/j.tetlet.2009.06.090 Zobrazit plný text záznamu Full Text from ScienceDirect