Regulative Roles of Ghrelin in Ingestive Behavior, Upper Gastrointestinal Motility, and Secretion
| Autor: | Akio Inui, Akihiro Asakawa, Shouichi Miyawaki, Takakazu Yagi, Hirotaka Ueda, Haruka Amitani |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Gastric emptying Stomach digestive oral and skin physiology Public Health Environmental and Occupational Health Gastric motility Motility Biology Endocrinology medicine.anatomical_structure Growth hormone secretagogue Internal medicine medicine Gastric acid Ghrelin Secretion hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Current Nutrition & Food Science. 8:188-195 |
| ISSN: | 1573-4013 |
| DOI: | 10.2174/157340112802651112 |
| Popis: | Ghrelin was recently identified as the first endogenous ligand for growth hormone secretagogue receptors (previously known as orphan receptors). Two major molecular forms of ghrelin are found in the stomach and plasma: acyl ghrelin with O-n-octanoylated serine at position 3 and des-acyl ghrelin. Interestingly, these distinct molecular forms play contrasting roles in ingestive behavior, upper gastrointestinal motility, and gastric acid secretion. Acyl ghrelin stimulates food intake both in fed and fasted rodents and induces adiposity, alleviates ingestive behavior, stimulates gastrointestinal motor activity and gastric acid secretion, and accelerates gastric emptying in several species. In contrast, des-acyl ghrelin has been demonstrated to disrupt gastric motility in rats and delay gastric emptying in mice and rats. Thus, acyl ghrelin is a potent stimulator of ingestive behavior, gastrointestinal motility, and gastric acid secretion, whereas des-acyl ghrelin exerts opposing effects on ingestive behavior and gastrointestinal motility but does not affect gastric acid secretion. Ghrelin is expected to be used in various applications such as therapeutic strategies for obesity, anorexia, cachexia, and cardiovascular disease in the clinical setting. In this article, we review the evidence on the roles of acyl ghrelin and des-acyl ghrelin in the regulation of ingestive behavior, upper gastrointestinal motility, and gastric acid secretion in mammals; moreover, we mention the effects of ghrelin on oral functions. |
| Databáze: | OpenAIRE |
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