Serotonin Content of the Lungs, Brains, and Blood of Mice Exposed to 0.45 ppm Nitrogen Dioxide
| Autor: | J. D. Lee, R. Ransom, R. P. Sherwin, J. C. Shih |
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| Rok vydání: | 1986 |
| Předmět: |
SWISS WEBSTER
medicine.medical_specialty Lung Ratón 030206 dentistry Metabolism Biology Toxicology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology medicine.anatomical_structure chemistry Internal medicine Young adult male Toxicity medicine Nitrogen dioxide Serotonin |
| Zdroj: | Journal of the American College of Toxicology. 5:583-588 |
| ISSN: | 0730-0913 |
| Popis: | Young adult male Swiss Webster mice were exposed to 0.45 ppm of nitrogen dioxide (NO2) for 7 hours per day for 4 weeks. The lungs and brains were assayed for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content by high-performance liquid chromatography. Lung 5-HT content for the exposed animals was 13.1% less than that for the control group, but this difference was not statistically significant. Brain 5-HT and 5-HIAA were significantly elevated, +17.3% (P < 0.005) and +47.3% (P 0.001), respectively, and the ratios of 5-HIAA to 5-HT were also higher (P 0.005). The results suggest that further exploration of lung and brain serotonin alterations by air pollutants may offer useful discriminates for the evaluation of air quality. |
| Databáze: | OpenAIRE |
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