Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis

Autor:	Hanae Yamada, Masumi Hara, Risa Yamashita, Atsuko Takai, Kentaro Kikuchi, Yusuke Kajiyama, Masatsugu Negishi, Hiroshi Miyakawa, Hiromichi Tsunashima, Kotaro Matsumoto, Koichi Tsuneyama, Yuki Moritoki
Rok vydání:	2014
Předmět:	Pathology medicine.medical_specialty Hepatology biology Follicular dendritic cells Spleen medicine.disease digestive system diseases Infectious Diseases medicine.anatomical_structure Primary biliary cirrhosis Immunoglobulin M Splenic Tissue medicine biology.protein Lymph CXCL13 Antibody
Zdroj:	Hepatology Research. 44:E253-E256
ISSN:	1386-6346
DOI:	10.1111/hepr.12231
Popis:	Aim To reveal the site of immunoglobulin (Ig)M production in primary biliary cirrhosis (PBC) we performed immunohistochemical analysis on spleens collected from patients with PBC. Methods Splenic tissue samples were collected at the time of the autopsy from patients with hepatic failure. Immunostaining for IgM, CD21 and CXCL13 were performed using the splenic tissue samples. Results The samples from five out of eight cases with PBC but not in eight cases of chronic hepatitis C virus infection showed accumulation of IgM positive cells in CD21 positive lymph follicles. The CXCL13 positive cells also accumulated in the center of the lymph follicles where the IgM positive cells accumulated. Conclusion The present results suggest that excess IgM is produced from the spleen of PBC. Furthermore, it was suggested that CXCL13 positive follicular dendritic cells possibly contribute to this process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b168d6491ee532c77b00b6b21692317 https://doi.org/10.1111/hepr.12231 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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