Photoaffinity analog of herbicide inhibiting cellulose biosynthesis: Synthesis of [3H]-2,6-dichlorophenylazide

Autor:	Deborah P. Delmer, Carmen I. Nitsche, Geoffrey Cooper
Rok vydání:	1987
Předmět:	Chemistry Organic Chemistry Cellulose biosynthesis Biochemistry Analytical Chemistry chemistry.chemical_compound Biosynthesis In vivo Drug Discovery Radiology Nuclear Medicine and imaging Low molecular weight protein Tritium Fiber Cellulose 2 6-Dichlorobenzonitrile Spectroscopy
Zdroj:	Journal of Labelled Compounds and Radiopharmaceuticals. 24:759-761
ISSN:	0362-4803
DOI:	10.1002/jlcr.2580240705
Popis:	The compound 2,6-dichlorobenzonitrile (dichlobenil, DCB) is known to be a reversible inhibitor of in vivo cellulose biosynthesis in higher plants and algae. We now report the synthesis of 2,6-dichlorophenylazide (DCPA) with a non-exchangeable tritium label of high specific activity. We have shown this compound to compete with DCB in binding to cotton fiber extracts, and to specifically label a low molecular weight protein in this extract on irradiation with UV light.
Databáze:	OpenAIRE
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