Phase I study of intraarterial mitomycin-c for recurrent intracerebral tumors

Autor:	Brian Luke, Brien Benoit, Herman Hugenholtz, David J. Stewart, Jean Dennery, Eric Peterson, Enrique C. G. Ventureyra, Jean A. Maroun, Neville Russell, Zvonimir Grahovac, Michael T. Richard, Harry S. Hopkins, André Girard
Rok vydání:	1986
Předmět:	medicine.medical_specialty business.industry Vertebral artery Mitomycin C medicine.disease Phase i study Ocular toxicity Regimen medicine.artery Primitive neuroectodermal tumor Medicine Radiology Internal carotid artery business Brain metastasis
Zdroj:	Biology of Brain Tumour ISBN: 9781461294153
DOI:	10.1007/978-1-4613-2297-9_65
Popis:	Seventeen patients with intracerebral neoplasms were treated with intra-arterial mitomycin-c 7.5–18 mg/m2 at 6–9 week intervals. Most were heavily pretreated. Three of 8 evaluable patients with brain metastases, a single patient with a primitive neuroectodermal tumor, and 0 of 6 with glioblastomas responded to treatment. The activity of this regimen to date has been impressive considering the patient population treated. Neurological and ocular toxicity were dose-limiting. We recommend a mitomycin-c dose of 15 mg/m2 every 6–9 weeks for further studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3b0e7461692b55c031f17d391106695e https://doi.org/10.1007/978-1-4613-2297-9_65 Zobrazit plný text záznamu