The ureides of p -aminophenylstibinic acid
| Autor: | H. W. Bainbridge, W. H. Gray, John William Trevan, A. P. Attwood |
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| Rok vydání: | 1931 |
| Předmět: | |
| Zdroj: | Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. 108:54-83 |
| ISSN: | 2053-9185 0950-1193 |
| DOI: | 10.1098/rspb.1931.0021 |
| Popis: | 1. Indian kala-azar is a widespread disease which ran a fatal course, un-influenced by drugs, until it was found that it could be cured by tartar emetic (Di Cristina and Caronia, 1915; Rogers, 1915; Muir, 1915). more recently it has been shown by a number of workers that certain organic antimony compounds can be used with more advantage. These are far less toxic in proportion to their curative power, and are thus suitable for intensive administration. Several of the more important are simple derivatives of p -aminophenylstibinic acid (stibanilic acid), of known constitution, for example, the sodium salts of the glucosyl-(stibamine glucoside) and the 3-chloro-4-acetyl-derivatives, also the diethylamine salt of the acid itself. Apart from these, the most interesting is a material prepared by heating stibanilic acid with urea solution, introduced by Brahmachari (1922) under the name “urea stibamine,” the nature of which has been subject of conflicting opinions by other workers as well as by Brahmachari himself. As this substance is in extended use in India, and it is important from the point of view of progress in chemotherapy that the constitution of useful drugs should not remain undetermined, the present investigation, with the initial object of elucidating this, was undertaken. 2. At the outset the product was found to be, not ammonium p -carbamidophenylstibinate, which is Brahmachari's latest view (1924), but a somewhat complicated mixture of colloids. Only partial separation of its constituents could be effected by chemical means, which, however, sufficed to show that this ammonium salt could not be present to any considerable extent, and to indicate the presence of the essential active substance with respect to mouse trypanosomiasis ( Trypanosoma equiperdum ), s -diphenylcarbamide-4:4'-distibinic acid. Verification of this was afforded by preparation of these two ureides by separate and simpler methods and comparison of their physiological properties with those of “urea stibamine (Brahmachari).” |
| Databáze: | OpenAIRE |
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