Protocatechuic acid and saponin mixture from Steganotaenia araliacea stem bark
| Autor: | T. A. Olugbade, Taiwo E. Alemika, Grace O. Onawunmi |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Steganotaenia araliacea
chemistry.chemical_classification Antioxidant Apiaceae Traditional medicine biology Chemistry medicine.medical_treatment Saponin Ethyl acetate Fractionation biology.organism_classification Antimicrobial Protocatechuic acid chemistry.chemical_compound medicine Organic chemistry |
| Zdroj: | Nigerian Journal of Pharmaceutical Research. 3 |
| ISSN: | 0189-8434 |
| DOI: | 10.4314/njpr.v3i1.35378 |
| Popis: | Steganotaenia araliacea Hochst (Apiaceae / Umbelliferae) is used in East and West African ethnomedicine for treating gastro-intestinal disorders, peptic ulcer, rheumatism and various diseases of microbial origin. The plant was therefore investigated for its chemical constituents while testing for possible antimicrobial, antioxidant, spasmolytic and anti-inflammatory activities. Through bioactivity-driven fractionation, protocatechuic acid was isolated from the ethyl acetate fraction as the main antimicrobial (agar diffusion) and antioxidant (radical scavenging-DPPH) principle. The crude extract exhibited spasmolytic activity, which was found to reside exclusively in the aqueous fraction. Further fractionation of the aqueous fraction yielded a saponin mixture. The observed spasmolytic effect was found to be antihistaminic rather than anticholinergic. The saponin mixture also demonstrated significant anti-inflammatory activity. At a dose of 1 mg/kg i.p. it gave a 77.7% inhibition of carrageenan-induced rat-paw oedema. Key words: Steganotaenia araliacea ; Saponins; Antimicrobial; Antioxidant; Spasmolytic; Antiinflammatory Nig. J. Pharm. Res. 3(1) 2004: 9-15 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|