Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model
| Autor: | Peiru Wang, Lei Shi, Haiyan Zhang, Xiuli Wang, Feng Zhao, Qingfeng Tu, Linglin Zhang, Zheng Huang, Xiaojie Wang, Hongwei Wang, Hansen Luan |
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| Rok vydání: | 2015 |
| Předmět: |
Cutaneous squamous cell carcinoma
Protoporphyrin IX medicine.medical_treatment technology industry and agriculture Photodynamic therapy macromolecular substances medicine.disease Hairless stomatognathic diseases chemistry.chemical_compound PLGA Immune system chemistry medicine Cancer research Basal cell Skin cancer neoplasms therapeutics |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2077939 |
| Popis: | Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC. Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin IX (PpIX) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined. Results: PLGA NPs could enhance PpIX production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC. Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC. |
| Databáze: | OpenAIRE |
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