Diastereoselection in the LiA1H4 reduction of severely hindered β-diketones examples of -curtin-hammett preequilibrium conditions

Autor:	Antonio C. Siani, Jorge Marquet, M. E. Lloris, Nicanor Gálvez, Marcial Moreno-Mañas
Rok vydání:	1992
Předmět:	Diketone Reduction (complexity) chemistry.chemical_compound Chemistry Organic Chemistry Drug Discovery Diol Organic chemistry Curtin–Hammett principle Aliphatic compound Biochemistry Conformational isomerism
Zdroj:	Tetrahedron. 48:3603-3610
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)88498-2
Popis:	LiA1H4 Reduction of α-adamantyl(and tert-butyl)-β-diketones occur under anti-Curtin-Hammett preequilibrium conditions, each preferred conformer leading to a different stereoisomeric diol, whereas reduction of 3-adamantyl-3-methyl(and ethyl)pentane-2-,4-dione occurs with high diastereoselectivity to afford only the (2R,3r,4S) meso diol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3aff16ecc77519457c8191688648f3d9 https://doi.org/10.1016/s0040-4020(01)88498-2 Zobrazit plný text záznamu