Síndrome de Sjögren y afectación pulmonar
| Autor: | Roser Solans-Laqué, Jaume Mestre-Torres |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Autoimmune disease
Exocrine gland medicine.medical_specialty Bronchiectasis Anti-nuclear antibody business.industry General Medicine medicine.disease Dermatology Pulmonary function testing Transplantation stomatognathic diseases medicine.anatomical_structure Sicca syndrome medicine Respiratory system business |
| Zdroj: | Medicina Clínica. 158:181-185 |
| ISSN: | 0025-7753 |
| Popis: | Sjogren's syndrome is an autoimmune disease that involves exocrine glands. The most characteristic symptoms consist of the sicca syndrome (including xerostomia and dry eye - xerophtalmia), but can involve multiple organs. The extraglandular involvement determines the prognosis. It is typically associated with the presence of antinuclear antibodies, including Ro-60 antibodies. Pulmonary involvement appears as bronchiectasis and/or interstitial pneumonia. Considering its high prevalence, it must be ruled out in all patients with respiratory symptoms by performing pulmonary function tests and high-resolution computed tomography of the chest. Evaluation can be completed with a transbronchial biopsy if diagnostic doubts persist. Treatment includes steroid therapy, inmunosupressive or antifibrotic drugs, or biological therapy. In selected cases pulmonary transplantation must be considered. |
| Databáze: | OpenAIRE |
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