Kontrastmittelkinetik in zerebralen Tumoren

Autor:	S. Lange, Th. Grumme, E. Kazner, Harald Steinhoff, Ch. Aviles
Rok vydání:	1979
Předmět:	Pathology medicine.medical_specialty Single compartment business.industry Clinical diagnosis media_common.quotation_subject medicine Contrast (vision) Radiology Nuclear Medicine and imaging Tumor type Compartment (pharmacokinetics) business media_common
Zdroj:	RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 130:666-669
ISSN:	1438-9010 1438-9029
DOI:	10.1055/s-0029-1231351
Popis:	The increase in density of cerebral tumours following intravenous injection of contrast media was measured by computer tomography and was evaluated quantitatively. The density increase of 158 tumours five minute after injection was between 0 and 29 CT units. There are considerable variations in density increase of various types of tumour, but the scatter is so wide as to preclude a diagnosis of tumour type. In 75 tumours repeated measurement of contrast changes were carried out for two hours following the injection. Again the variation differs with different types of tumour, but is not characteristic enough for exact clinical diagnosis. In 26 patients contrast concentrations were measured in the tumour and the blood and a pharmaco-kinetic compartmental analysis was carried out. In some tumours contrast changes can be explained by a single compartment model, whereas in others a two compartment model is necessary. Certain conclusions regarding the mechanism of contrast uptake can be reached.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3aef0e8803126f4fe8ae8953933c345f https://doi.org/10.1055/s-0029-1231351 Zobrazit plný text záznamu