Collagen cross-linking: new dimension to cardiac remodeling
| Autor: | Himanshu H. Shukla, Hanumanth K. Reddy, Santhosh K. G. Koshy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Cardiac cycle Physiology business.industry Cardiac myocyte Diastole medicine.disease Hypertensive heart disease medicine.anatomical_structure Ventricle Physiology (medical) Cardiac chamber Heart failure Internal medicine Cardiology Medicine Myocyte Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Research. 57:594-598 |
| ISSN: | 0008-6363 |
| DOI: | 10.1016/s0008-6363(02)00877-5 |
| Popis: | See article by Badenhorst et al. [1] (pages 632–641) in this issue. Left ventricular (LV) dysfunction has become a leading area of research as the prevalence of heart failure is reaching epidemic proportions. LV chamber remodeling and stiffness are consequent to significant structural and functional alteration of both the myocyte and extracellular matrix (ECM). Both these factors are important determinants of chamber size and geometry as well as its contractile and relaxation properties. Numerous papers have been published about the seminal role of collagen concentration and collagenolysis in hypertrophic and dilated cardiomyopathies; however, the qualitative aspects of these changes were not correlated well with the functional characteristics of cardiac chambers. In this issue of Cardiovascular Research , Baldenhorst et al. [1] show the influence of collagen cross-linking on chamber stiffness and remodeling. Cellular mechanisms responsible for transformation of compensatory myocardial hypertrophy to a dysfunctional dilated ventricle remain enigmatic. Earlier studies focused on structural changes in the cardiac myocyte to explain chamber dysfunction in hypertensive heart disease [2–5]. This included studies related to changes in its size and spatial orientation [2–4]. The depression of systolic function and an increase in passive stiffness were noted even in isolated muscle preparations [5]. This suggested that physiological changes in the myocardial chamber were related to structural changes at the cardiac myocyte level. More recent studies have focused on the contribution of the ECM to cardiac contraction and relaxation functions [6–11]. The collagen matrix provides support for the maintenance of both myocyte and myofibrillar alignment, thereby ensuring structural integrity for individual myocyte shortening and relaxation, which then translates into overall myocardial systolic and diastolic properties. Therefore, the patterns of collagen synthesis and degradation play a seminal role in determining the altered systolic and diastolic properties of a remodeled ventricle in response … * Corresponding author. DC 034.00, Division of Cardiology, University of Missouri—Columbia, 1 Hospital Drive, Columbia, MO 65212, USA. Tel.: +1-573-882-2296; fax: +1-573-884-7743. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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