Prognostic Impact of Absolute Lymphocyte Count/Absolute Monocyte Count Ratio and Prognostic Score in Patients with Nasal Type, Extranodal Natural Killer/T Cell Lymphoma
| Autor: | Na Li, Li Zhang, Hua-wei Weng, Hao-lan Song, Jing Zhang, Liqun Zou |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty education.field_of_study Receiver operating characteristic business.industry Immunology Population Absolute lymphocyte count Cell Biology Hematology medicine.disease Natural killer T cell Biochemistry Gastroenterology Lymphoma Prognostic score Monocyte count Internal medicine medicine T-cell lymphoma education business |
| Zdroj: | Blood. 128:5307-5307 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Nasal type, extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a heterogeneous disorder with poor prognosis, requiring risk stratification in this population. We designed to investigate the prognostic significance of absolute lymphocyte count (ALC), absolute monocyte count (AMC), ALC/AMC ratio and ALC/AMC prognostic score (low risk, normal ALC and AMC; intermediate risk, low ALC or high AMC; high risk, low ALC and high AMC) and to determine whether ALC/AMC ratio or prognostic score is a better predictor of prognosis in ENKTL. A total of 264 patients with newly diagnosed ENKTL were retrospectively analyzed in present study. Receiver Operating Curve analysis showed that optimal cut-off values of ALC, AMC and ALC/AMC ratio were 1.0×109/L, 0.5×109/L and 2.85, respectively. In multivariate analysis all tested factors including ALC, AMC, ALC/AMC ratio and prognostic score were independent risk factors. After a median follow-up of 30 months (range 1-87), an estimated 3-year overall survival (OS) in the 264 patients was 75.4%. Patients with ALC/AMC ratio≥2.85 had a better OS and progression-free survival (PFS) than those with ALC/AMC ratio Disclosures No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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