Susceptibility of sequential Fonsecaea pedrosoi isolates from chromoblastomycosis patients to antifungal agents. Antimykotika-Empfindlichkeit von sequenziellen Fonsecaea pedrosoi-Isolaten von Chromoblastomykose-Patienten

Autor:	Tânia Sueli de Andrade, Luiz Guilherme Martins Castro, Viviane M F Gimenes, Ricardo Spina Nunes, Arlete Emily Cury
Rok vydání:	2004
Předmět:	Chromoblastomycosis biology Itraconazole Dermatology General Medicine biology.organism_classification medicine.disease Microbiology Fonsecaea pedrosoi Minimum inhibitory concentration Infectious Diseases Amphotericin B medicine Terbinafine Ketoconazole Fluconazole medicine.drug
Zdroj:	Mycoses. 47:216-221
ISSN:	1439-0507 0933-7407
DOI:	10.1111/j.1439-0507.2004.00984.x
Popis:	Fourteen Fonsecaea pedrosoi isolates from six chromoblastomycosis patients were submitted to susceptibility testing. Some patients were undergoing treatment with itraconazole (ITZ) and/or cryosurgery with liquid nitrogen. The antifungal agents amphotericin B (AMB), ITZ, fluconazole (FCZ), ketoconazole (KCZ), 5-fluorocytosine (5-FC), and terbinafine (TBF) were tested. AMB and FCZ showed less activity for all isolates. The most active agents were KCZ and TBF. Sequentially isolates from four patients presented ITZ minimal inhibitory concentration (MIC) higher than the previous ones; for two of these patients, response to therapy with this agent was not observed. These results suggest development of microbiologic resistance to ITZ in four instances, two of them coinciding with lack of clinical response to this drug.
Databáze:	OpenAIRE
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