The use of enantiomerically pure N-sulfinimines in asymmetric Baylis–Hillman reactions

Autor:	Ana M. Martin Castro, Andrea Mereu, Varinder K. Aggarwal, Harry Adams
Rok vydání:	2002
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Electrophile Organic chemistry Lewis acids and bases Methyl acrylate Biochemistry
Zdroj:	Tetrahedron Letters. 43:1577-1581
ISSN:	0040-4039
Popis:	The electrophilic behaviour of enantiomerically pure N - p -toluenesulfinimines ( 1a – d ) and N - tert -butanesulfinimine 2 has been tested in the asymmetric Baylis–Hillman reaction with methyl acrylate with and without Lewis acids. In the presence of In(OTf) 3 good yields and high diastereoselectivities have been achieved providing an effective route to β-amino-α-methylene esters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3ac24bb9210cead6a1878f1747fb056e https://doi.org/10.1016/s0040-4039(02)00021-7 Zobrazit plný text záznamu Full Text from ScienceDirect