| Autor: |
Thomas J. Marrie, R. B. Light, Godfrey K. M. Harding, L. Thompson, Frederick J. Buckwold, Allan R. Ronald |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
JAMA. 242:1975 |
| ISSN: |
0098-7484 |
| DOI: |
10.1001/jama.1979.03300180019023 |
| Popis: |
Thirty-two women with recurrent urinary tract infections were treated after eradication of existing infections with a mixture of 40 mg of trimethoprim and 200 mg of sulfamethoxazole thrice weekly at bedtime for six months. Six preadolescents received one half this dose. During 21.3 cumulative patient-years of prophylaxis, one infection due toStreptococcus faecalisand one due to a sulfamethoxazole- and trimethoprim-sensitiveEscherichia colioccured—an infection incidence of 0.1 per patient-year. During prophylaxis, 61 of 72 periurethral cultures and 24 of 51 anal canal cultures failed to yield Enterobacteriaceae. One patient had transient colonization with a trimethoprim-resistantE coliduring prophylaxis. Twenty-one patients had recurrent infection within six months of discontinuation of prophylaxis, with a mean time to recurrence of 2.6 months. One infection recurred 26 weeks following prophylaxis with aProteus mirabilis. Thrice-weekly trimethoprim-sulfamethoxazole therapy was effective for prophylaxis of recurrent urinary tract infections and did not predispose to colonization or infection with trimethoprim-resistant Enterobacteriaceae. (JAMA242:1975-1977, 1979) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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