Lincomycin–embedded PANI–based coatings for biomedical applications
| Autor: | Bogdan Stefan Vasile, Valentina Grumezescu, Marcela Socol, Alina-Maria Holban, Gabriel Socol, Oana Fufă, Diana Savu, Gianina Popescu-Pelin, Irina Zgura, Roxana Cristina Popescu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Maple
Materials science Simulated body fluid Composite number General Physics and Astronomy 02 engineering and technology Surfaces and Interfaces General Chemistry engineering.material 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Evaporation (deposition) 0104 chemical sciences Surfaces Coatings and Films chemistry.chemical_compound chemistry Chemical engineering Polyaniline engineering Antimicrobial surface Fourier transform infrared spectroscopy 0210 nano-technology Magnetite |
| Zdroj: | Applied Surface Science. 455:653-666 |
| ISSN: | 0169-4332 |
| Popis: | We report on the successful laser transfer of biocompatible composite coatings based on polyaniline (PANI) embedded with magnetite (PANI-Fe3O4) and Lincomycin hydrochloride (PANI-Lincomycin) or Lincomycin-functionalized magnetite (PANI-Fe3O4@Lincomycin) by matrix assisted pulsed laser evaporation (MAPLE) technique. The physico-chemical investigations revealed relevant data regarding the stoichiometric deposition, morphology and topography of the as-deposited coatings. Regarding the MAPLE coatings, the FTIR studies evidenced the vibrational bands characteristic to pristine PANI material, while the SEM investigations unveiled a preferential particulate morphology (with aggregates shape and size depending on the deposited material). Additionally, the AFM measurements indicated variations of RMS value, following the Lincomycin and magnetite incorporation. The wettability measurements displayed a hydrophilic behavior of the synthesized coatings, while the electrochemical studies emphasized an enhanced resistance against corrosion in simulated body fluid when compared with bare Ti. Cellular viability, immunofluorescence and SEM results proved that the MAPLE coatings were suitable materials for beneficial adhesion, spreading and proliferation of osteoblast-like cells (MG-63). Moreover, an increased efficiency was evidenced against Staphylococcus aureus biofilm development. The multifunctional properties of the laser processed composite coatings – confirmed by cumulative biocompatible, antimicrobial and anticorrosive behaviors – recommend them as promising solutions for biomedical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect