Application with bioadhesive Eudispert gel preparations containing ONO-4057, a new drug for ulcerative colitis, for rectal drug delivery
| Autor: | Nak-Seo Kim, Shigeru Goto, Hiroyuki Umejima, Takahiro Harada, Takahiro Uchida |
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| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Drug Delivery System. 9:363-369 |
| ISSN: | 1881-2732 0913-5006 |
| Popis: | Eudispert hv hydrogel and xerogel preparations containing ONO-4057(5-[2-carboxyethyl)3-{6-(4-methoxyphenyl)-5E-hexenyl}oxyphenoxy]valeric acid), a new leukotriene B4 antagonist, were prepared, and evaluated in rats following rectal administration of these preparations. For rectal administration of gel preparations, the absolute bioavailability of ONO-4057 was almost the same (approximately 30%) as that for oral administration (31%) and also quite low compared with those of Witepsol H-15 or PEG 2000 suppositories (37% and 56%). The residual amounts in the intestine and rectum tubes and the accumulative amounts in the intestine and rectum tissues of ONO-4057 following oral and rectal administrations of various preparations were measured. The results indicate that the residual and accumulative amounts of ONO-4057 for eudispert hv gel preparations increased 2∼5 folds compared with administration of oral and two conventional suppositories. Accordingly, it is assumed that eudispert hv hydrogel and xerogel preparations have excellent staying properties in the lower part of rectum and can directly act to focus parts of ulcerative colitis by raising ONO-4057 concentrations in rectum and its tissue. |
| Databáze: | OpenAIRE |
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