Stroke following Glenn anastomosis in a child with inherited thrombophilia
| Autor: | Ioannis Germanakis, Eleftheria Papadopoulou, Maria Raissaki, Maria Kalmanti, George E. Sarris, Spyridon Rammos, Caterina Sfyridaki |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
biology business.industry Anastomosis medicine.disease Thrombophilia Thrombosis Double inlet left ventricle Internal medicine Methylenetetrahydrofolate reductase medicine Cardiology biology.protein Heart bypass Family history Cardiology and Cardiovascular Medicine business Stroke |
| Zdroj: | International Journal of Cardiology. 111:464-467 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2005.07.013 |
| Popis: | The optimal anticoagulation following Fontan operation and its modifications remain controversial and it is even less well defined as regards patients with inherited thrombophilia. We present a case of a child with bidirectional Glenn anastomosis for double inlet left ventricle that suffered a stroke despite aspirin prophylaxis; the patient was combined homozygous for prothrombin G20210A mutation and for methylenetetrahydrofolate reductase C677T mutation as well. The family history was positive for fetal loss and premature cardiovascular disease. Large-scale studies are needed to evaluate whether carriers of thrombophilia mutations need more intense thromboprophylaxis. |
| Databáze: | OpenAIRE |
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