Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [11C]raclopride study in humans
| Autor: | Sylvia M. L. Cox, Chawki Benkelfat, Alain Dagher, J. Scott Delaney, France Durand, Theodore Kolivakis, Kevin F. Casey, Marco Leyton |
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| Rok vydání: | 2011 |
| Předmět: |
Raclopride
Striatal dopamine medicine.medical_specialty Dopaminergic Tryptophan 030218 nuclear medicine & medical imaging 11c raclopride 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Endocrinology Dopamine Internal medicine medicine Nasal administration Serotonin Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | British Journal of Psychiatry. 199:391-397 |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | BackgroundLow serotonin transmission is thought to increase susceptibility to a wide range of substance use disorders and impulsive traits.AimsTo investigate the effects of lowered serotonin on cocaine-induced (1.0 mg/kg cocaine, self-administered intranasally) dopamine responses and drug craving.MethodIn non-dependent cocaine users, serotonin transmission was reduced using the acute tryptophan depletion method. Striatal dopamine responses were measured using positron emission tomography with [11C]raclopride.ResultsAcute tryptophan depletion increased drug craving and striatal dopamine responses to cocaine. These acute tryptophan depletion-induced increases did not occur in the absence of cocaine.ConclusionsThe results suggest that low serotonin transmission can increase dopaminergic and appetitive responses to cocaine. These findings might identify a mechanism by which individuals with low serotonin are at elevated risk for both substance use disorders and comorbid conditions. |
| Databáze: | OpenAIRE |
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