Brain metabolite composition during early human brain development as measured by quantitative in vivo1H magnetic resonance spectroscopy
| Autor: | Beatrice Kuhlmann, Christoph Hans Boesch, Petra Susan Hüppi, Roland Kreis, Lucie Hofmann, Emilio Bossi |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Taurine Metabolite Population Central nervous system Glutamate receptor Gestational age Human brain Glutamine chemistry.chemical_compound Nuclear magnetic resonance medicine.anatomical_structure Endocrinology chemistry Internal medicine medicine Radiology Nuclear Medicine and imaging education |
| Zdroj: | Magnetic Resonance in Medicine. 48:949-958 |
| ISSN: | 0740-3194 |
| DOI: | 10.1002/mrm.10304 |
| Popis: | Biochemical maturation of the brain can be studied noninvasively by (1)H magnetic resonance spectroscopy (MRS) in human infants. Detailed time courses of cerebral tissue contents are known for the most abundant metabolites only, and whether or not premature birth affects biochemical maturation of the brain is disputed. Hence, the last trimester of gestation was observed in infants born prematurely, and their cerebral metabolite contents at birth and at expected term were compared with those of fullterm infants. Successful quantitative short-TE (1)H MRS was performed in three cerebral locations in 21 infants in 28 sessions (gestational age 32-43 weeks). The spectra were analyzed with linear combination model fitting, considerably extending the range of observable metabolites to include acetate, alanine, aspartate, cholines, creatines, gamma-aminobutyrate, glucose, glutamine, glutamate, glutathione, glycine, lactate, myo-inositol, macromolecular contributions, N-acetylaspartate, N-acetylaspartylglutamate, o-phosphoethanolamine, scyllo-inositol, taurine, and threonine. Significant effects of age and location were found for many metabolites, including the previously observed neuronal maturation reflected by an increase in N-acetylaspartate. Absolute brain metabolite content in premature infants at term was not considerably different from that in fullterm infants, indicating that prematurity did not affect biochemical brain maturation substantially in the studied population, which did not include infants of extremely low birthweight. |
| Databáze: | OpenAIRE |
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