Efficient method for the preparation of 2α,3β-dichcloro-4,4,10-trimethyl-decalin systems as a route for the synthesis of dichlorolissoclimide

Autor:	Michael E. Jung, Angel Vidal Gomez
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Bicyclic molecule Chemistry Organic Chemistry Dichlorolissoclimide Ring (chemistry) Biochemistry Haloketone chemistry.chemical_compound Decalin Yield (chemistry) Drug Discovery Organic chemistry Thermal reaction
Zdroj:	Tetrahedron Letters. 34:2891-2894
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60473-2
Popis:	An efficient synthesis of diequatorial dichlorinated trimethyldecalin derivatives, analogues of the AB ring of the strongly cytotoxic agent dichlorolissoclimide 1, is described. The key step involves a thermal diaxial to diequatorial dichloride rearrangement in good yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3aa0ffc16f6986c1e208d88b4d17299c https://doi.org/10.1016/s0040-4039(00)60473-2 Zobrazit plný text záznamu