Synthesis and biological evaluation of some stilbene-based analogues
| Autor: | Subhas S. Karki, Chitra G. Rajput, Ganesh S. Pedgaonkar, Girish S. Shendarkar, P. K. Zubaidha, Santosh Ramarao Bhutle, Rizwan M. Shaikh |
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| Rok vydání: | 2010 |
| Předmět: |
Antifungal
chemistry.chemical_classification Antioxidant biology medicine.drug_class Chemistry Stereochemistry medicine.medical_treatment Phytoalexin Organic Chemistry Resveratrol Penicillium chrysogenum biology.organism_classification In vitro chemistry.chemical_compound medicine General Pharmacology Toxicology and Pharmaceutics Antibacterial activity Biological evaluation |
| Zdroj: | Medicinal Chemistry Research. 20:1158-1163 |
| ISSN: | 1554-8120 1054-2523 |
| Popis: | The phytoalexin 3,5,4′-trihydroxy-trans-stilbene (resveratrol) has attracted considerable attention from biologists and chemists due to its diverse biological properties. Owing to the biological importance of this compound, we have synthesized new stilbene-based analogues by using substituted benzyl chlorides and substituted aldehydes in a two-step reaction and evaluated their in vitro antioxidant, antibacterial and antifungal potential. Most of the compounds displayed moderate to significant radical scavenging activity. (E)-1-(3,4-difluorophenyl)-2-(4-fluorophenyl)ethene (4c) showed nearer equipotent antibacterial activity against Staphylococcus aureus. (E)-1,2-bis(4-fluorophenyl)ethene (4a), (E)-1-(3-fluorophenyl)-2-(4-fluorophenyl)ethene (4b), (E)-1-(2,4-dichlorophenyl)-2-(3,4-dichlorophenyl)ethene (4f), (E)-1-(2,4-dichlorophenyl)-2-(3-chlorophenyl)ethene (4g), (E)-1-(2,4-dichlorophenyl)-2-(4-fluorophenyl)ethene (4j) (E)-1-(4-fluorophenyl)-2-(3-chlorophenyl)ethene (4l) and (E)-1-(4-chlorophenyl)-2-(4-fluorophenyl)ethene (4n) inhibited the growth of Penicillium chrysogenum. |
| Databáze: | OpenAIRE |
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