Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines

Autor:	Alexander S. Bunev, Stepanova Ev, D. A. Khochenkov, Yulia Khochenkova, Rovshan E. Gasanov, Yulia S. Machkova
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Isothiouronium Sulfide 010405 organic chemistry Chemistry General Chemistry Cell cycle 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Apoptosis LNCaP Cytotoxic T cell Moiety Malononitrile
Zdroj:	Mendeleev Communications. 30:604-606
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2020.09.017
Popis:	Novel 4-amino-5-cyano-2-sulfonylpyrimidines were prepared based on three-component cyclization between isothiouronium salts, benzaldehydes and malononitrile, followed by oxidation of the sulfide moiety with Oxone. The cytotoxic activity of the synthesized compounds, as well as the induction of apoptosis, inhibition of the cell cycle and proliferation tests were performed on selected cancer cell lines A431, A549, A375, HCT 116, MCF7, LNCap and SH-SY5Y.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a94c990410082dd9bb2ad256ec5d262 https://doi.org/10.1016/j.mencom.2020.09.017 Zobrazit plný text záznamu Full Text from ScienceDirect