Blimp-1 expressing lung ILC2s are a distinct cell population in allergic asthma
| Autor: | Jinyi Zhang, Kun He, B. Rhodes Ford, Angela Hettinga, Amanda C. Poholek |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 206:94.15-94.15 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Blimp-1 is a transcription factor known to have critical roles in multiple cell types including B, T and NK cells. However, its expression and function in non-NK innate lymphoid cell populations have not been well studied. To examine the expression and function of Blimp-1 in group 2 innate lymphoid cells, we analyzed several models of type 2 immunity. We found that Blimp-1 is not highly expressed in ILC2s at steady-state, however it is induced under specific stimulation conditions. Especially, Blimp-1 expression is substantially increased in house dust mite (HDM) activated mouse lung over time. In vivo and in vitro ILC2 stimulation with cytokines show that both IL-33 and IL-10 can induce Blimp-1 expression, indicating Blimp-1 is driven by multiple signals. Interestingly, HDM driven Blimp-1 expressing ILC2 have a distinct transcriptional program compared to classically-activated ILC2s treated with IL-25 and IL-33. ILC2 that express Blimp-1 predominantly lack type 2 cytokine expression, suggesting Blimp-1 plays a role independent of cytokine production and may represent a unique functional state of ILC2 cells in settings of chronic antigen including allergic disease. Our findings therefore demonstrate a previously unappreciated Blimp-1 expressing ILC2 population with distinct features that may be important for type 2 mediated disease. |
| Databáze: | OpenAIRE |
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