ChemInform Abstract: An Efficient Synthesis of Enantiomerically Pure 2-[(2R)-Arylmorpholin-2-yl]ethanols, Key Intermediates of Tachykinin Receptor Antagonist

Autor:	Yukiko Iio, Tetsuya Fukazawa, Katsuyoshi Nakajima, Koki Ishibashi, Takahide Nishi
Rok vydání:	2010
Předmět:	Dihydroxylation Stereochemistry Chemistry Antagonist Mitsunobu reaction General Medicine Tachykinin receptor Catalysis
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
Popis:	We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2-[(2R)-arylmorpholin-2-yl]ethanols 1a–d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation of 4a–d was employed to introduce the required absolute stereochemistry, and cyclization of 7a–d was accomplished by the Mitsunobu reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a8930adca399e3028c82e1911a65c6c https://doi.org/10.1002/chin.199910160 Zobrazit plný text záznamu Plný text