ChemInform Abstract: A Convenient Copper-Catalyzed Direct Amination of Nitroarenes with O-Alkylhydroxylamines

Autor:	Kunihito Miyake, Norio Kawamura, Shinzo Seko
Rok vydání:	2010
Předmět:	Nitrobenzene Steric effects chemistry.chemical_compound chemistry Nitro Substituent chemistry.chemical_element General Medicine Copper Lone pair Medicinal chemistry Amination Catalysis
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199941073
Popis:	O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields. ortho- or para-Amination with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c–f, 14 and 22g.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a818c15e82d4bf628aa4c32b2251850 https://doi.org/10.1002/chin.199941073 Zobrazit plný text záznamu Plný text