Accelerated telomere shortening and telomerase activation in Fanconi's anaemia

Autor:	Patrice Richard, E. D. Carosella, F. Leteurtre, Xiaxin Li, G. Le Roux, Eliane Gluckman, Philippe Guardiola, Jean-Christophe Sergere
Rok vydání:	1999
Předmět:	medicine.medical_specialty Telomerase Bone marrow failure Hematology Biology medicine.disease Peripheral blood mononuclear cell Molecular biology Restriction fragment Telomere Endocrinology medicine.anatomical_structure Fanconi anemia Internal medicine Chromosome instability medicine biology.protein Bone marrow
Zdroj:	British Journal of Haematology. 105:883-893
ISSN:	0007-1048
Popis:	Fanconi's anaemia (FA) is an autosomal recessive disorder characterized by progressive bone marrow failure that often evolves towards acute leukaemia. FA also belongs to a group of chromosome instability diseases. Because telomeres are directly involved in chromosomal stability and in cell proliferation capacity, we examined telomere metabolism in peripheral blood mononuclear cells (PBMC). Telomere length was significantly shorter in 54 FA patient samples, compared to 51 controls (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a7493493c801e4592b80e11645eb16f https://doi.org/10.1046/j.1365-2141.1999.01445.x Zobrazit plný text záznamu Plný text