Rapid Dilapidation of Alcohol Using Magnesium Oxide and Magnesium Aspartate based Nanostructures: A Raman Spectroscopic and Molecular Simulation Approach
| Autor: | Syed Kamil, Subramanian Balakumar, Dhinasekaran Durgalakshmi, Subramani Karthikeyan, R. Ajay Rakkesh |
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| Rok vydání: | 2019 |
| Předmět: |
Nanostructure
Ethanol Polymers and Plastics Magnesium Nanoparticle chemistry.chemical_element Sintering Alcohol 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences symbols.namesake chemistry.chemical_compound chemistry Aspartic acid Materials Chemistry symbols 0210 nano-technology Raman spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 29:1390-1399 |
| ISSN: | 1574-1451 1574-1443 |
| DOI: | 10.1007/s10904-019-01105-3 |
| Popis: | Magnesium in the form of magnesium sulphate, magnesium oxide, magnesium hydroxide, and magnesium carbonate magnesium was conventionally in use as an effective antidepressant component. However, the concentration of these materials was high, varying from 150 to 500 mg per day. In recent days, nano-formulation of drugs is of high great interest due to its higher performance compare to the bulk structure. In the present work, MgO nanoparticle of size less than 10 nm have been synthesized by the wet chemical method with a sintering condition of 400 °C for 3 h. Magnesium aspartate was prepared from aspartic acid by modifying the prepared MgO nanoparticles. In vitro ethanol dilapidation studies at a various time interval and molecular docking interaction studies of MgO and Magnesium aspartate with NMDA receptors confirm that, these nanostructures compounds are suggestible as supplements for magnesium deficient and alcohol-induced depression. |
| Databáze: | OpenAIRE |
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