Factors Affecting the Size of Platelet Aggregates in Blood

Autor:	J K Horak, R T Solis, Peter S. Kennedy, J A Ware
Rok vydání:	1981
Předmět:	Lysis medicine.diagnostic_test Volume (thermodynamics) Chemistry medicine Biophysics Platelet Hematology Particle size Hematocrit Incubation Dilution Whole blood
Zdroj:	Thrombosis and Haemostasis. 46:725-730
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1653462
Popis:	SummaryFactors affecting the size distribution of platelet aggregates formed in whole blood were measured using an electronic particle counter. Lysis of red cells after dilution of blood for analysis allows detection of smaller aggregates without altering aggregate measurement. Differences in platelet response to increasing concentrations of ADP are detected by an increase in the mean size of platelet aggregates while the total volume of aggregates varies linearly with the volume of available platelets (r = .99). The mean aggregate size varies directly with the total volume of aggregates formed (r = .99). Mean aggregate size is inversely related to the packed red cell volume. As the reactivity of platelets is reduced by incubation with aggregation inhibitors at increasing concentrations, the mean size of aggregates becomes smaller, followed by a decrease in the total volume of aggregates. The total volume and mean size of aggregates formed after incubation with collagen and epinephrine, but not ADP, increases with time after venepuncture.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a6509d04a85d2fd706669cf3272b5bc https://doi.org/10.1055/s-0038-1653462 Zobrazit plný text záznamu