Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection?
| Autor: | Ales Vidlar, Vladimír Študent, Vilím Šimánek, Benno F. Zimmermann, Pavel Kosina, Jitka Ulrichová, Jitka Vostálová, Jan Vacek, Adéla Galandáková, Jana Vrbkova |
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| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Urinary system Significant difference bacterial infections and mycoses urologic and male genital diseases Placebo group female genital diseases and pregnancy complications RECURRENT UTI American cranberry food.food Surgery food Proanthocyanidin Internal medicine medicine Young adult business Survival analysis |
| Zdroj: | Phytotherapy Research. 29:1559-1567 |
| ISSN: | 0951-418X |
| Popis: | Most research on American cranberry in the prevention of urinary tract infection (UTI) has used juices. The spectrum of components in juice is limited. This study tested whether whole cranberry fruit powder (proanthocyanidin content 0.56%) could prevent recurrent UTI in 182 women with two or more UTI episodes in the last year. Participants were randomized to a cranberry (n = 89) or a placebo group (n = 93) and received daily 500 mg of cranberry for 6 months. The number of UTI diagnoses was counted. The intent-to-treat analyses showed that in the cranberry group, the UTIs were significantly fewer [10.8% vs. 25.8%, p = 0.04, with an age-standardized 12-month UTI history (p = 0.01)]. The Kaplan-Meier survival curves showed that the cranberry group experienced a longer time to first UTI than the placebo group (p = 0.04). Biochemical parameters were normal, and there was no significant difference in urinary phenolics between the groups at baseline or on day180. The results show that cranberry fruit powder (peel, seeds, pulp) may reduce the risk of symptomatic UTI in women with a history of recurrent UTIs. |
| Databáze: | OpenAIRE |
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