Platinum pyridinecarboxaldimine complexes containing boronate esters

Autor:	Stephen A. Westcott, Hanni A. Darwish, Robert J. Ireland, Liliya G. Nikolcheva, Haiwen Zhang, Andreas Decken, Jennifer L. Horton, Christopher M. Vogels, Mazen Saleh, Stephen J. Scales
Rok vydání:	2004
Předmět:	Chemistry Stereochemistry Organic Chemistry chemistry.chemical_element General Chemistry Platinum Cytotoxicity Boron Medicinal chemistry Catalysis
Zdroj:	Canadian Journal of Chemistry. 82:1692-1699
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v04-147
Popis:	Condensation of 2-pyridinecarboxaldehydes with 2-, 3-, and 4-H2NC6H4Bpin (pin = 1,2-O2C2Me4) gave the corresponding boron-containing pyridinecarboxaldimines (N–NBpin). Addition of these ligands to [PtCl2(coe)]2 (coe = cis-cyclooctene) gave complexes of the type cis-PtCl2(N–NBpin) in moderate yields. The platinum complexes have been examined for their potential cytotoxicities against OV2008 (human ovarian carcinoma) and the analogous cisplatin-resistant cell line C13. Key words: boronate esters, pyridinecarboxaldimines, cytotoxicity, platinum, boron.
Databáze:	OpenAIRE
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