The Pathogenic Role of CD4+ Tissue-Resident Memory T Cells Bearing T Follicular Helper-Like Phenotype in Pemphigus Lesions
| Autor: | Yun Zhou, Shengru Zhou, Huijie Yuan, Yaru Zou, Haiqin Zhu, Meng Pan, Jie Zheng |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
integumentary system Cell Biology Dermatology Biology medicine.disease Biochemistry Phenotype Desmoglein Pathogenesis Transcriptome 03 medical and health sciences Pemphigus 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Follicular phase Immunology medicine Molecular Biology Transcription factor IRF4 |
| Zdroj: | Journal of Investigative Dermatology. 141:2141-2150 |
| ISSN: | 0022-202X |
| DOI: | 10.1016/j.jid.2021.01.030 |
| Popis: | In skin lesions caused by pemphigus, a group of life-threatening autoimmune bullous diseases, an over-representation of CD4+ tissue-resident memory T (TRM) cells was found. We sought to investigate the contributions of CD4+ TRM cells to the severity and refractoriness of pemphigus and their role in local immunological pathogenesis. Our data showed that CD4+ TRM cells accumulated significantly in pemphigus skin lesions. These CD4+ TRM cells expressed a specific set of T follicular helper cell‒related costimulatory molecules. We also found that CD4+ TRM cells remaining in the lesions produced IL-17A and IL-21. In vitro, CD4+ TRM cells exhibited strong support and assistance to autoantibody production. Through transcriptomic sequencing and bioinformatics analysis, we identified that the transcription factor IRF4 was responsible for IL-21 overexpression and autoantibody production. Our results showed that T follicular helper-like CD4+ TRM cells in pemphigus lesions promoted local autoantibody production, resulting in the formation and recurrence of lesions, which supports targeting this cell subset in pemphigus treatment. IRF4 might serve as a potential therapeutic target. |
| Databáze: | OpenAIRE |
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