Biocompatible Microemulsions Based on Oleic Acid Modified with Piperidinium Surfactants

Autor:	A. B. Mirgorodskaya, R. A. Kushnazarova, O. A. Lenina, K. A. Petrov, L. Ya. Zakharova
Rok vydání:	2023
Předmět:	General Chemistry
Zdroj:	Russian Journal of General Chemistry. 93:593-600
ISSN:	1608-3350 1070-3632
Popis:	Abstract A series of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances have been investigated. Varying of the components ratio has allowed preparation of the microemulsions with strongly different viscosity: from easy-flowing formulations to gels. Kinetic parameters describing release of the substrates from the microemulsions have been obtained. In vivo tests of the anti-inflammatory action of the microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a51cd11c35935cba1315be31c5833d2 https://doi.org/10.1134/s1070363223030167 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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