(S)-5,6-Dimethoxy-1,2,3,4-tetrahydro-2-naphthalenamine– L-(+)-Mandelic Acid (1/1): the Absolute Configuration of a Precursor of the Active Stereoisomer of 5,6-ADTN, an Important Dopaminergic Agonist
| Autor: | Mario Nardelli, M. Fantucci, Sandra Ianelli, S. Montanari, F. Santangelo |
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| Rok vydání: | 1996 |
| Předmět: |
Agonist
biology Bicyclic molecule medicine.drug_class Stereochemistry Dopaminergic Absolute configuration General Medicine Mandelic acid General Biochemistry Genetics and Molecular Biology Apomorphine chemistry.chemical_compound chemistry medicine biology.protein Carboxylate medicine.drug Organic anion |
| Zdroj: | Acta Crystallographica Section C Crystal Structure Communications. 52:3147-3150 |
| ISSN: | 0108-2701 |
| DOI: | 10.1107/s0108270196009614 |
| Popis: | The structure determination of the title compound, C12H18NO2+.C8H7O3−, has allowed the absolute configuration of the cation to be established. The base, demethylated, is 5,6-dihydroxy-1,2,3,4-tetrahydro-2-naphthalenamine, or 5,6-ADTN, and is responsible for the dopaminergic activity; this work shows that it has the same spatial arrangement as (6aR)-apomorphine. |
| Databáze: | OpenAIRE |
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