Helicobacter pylori -positive duodenal ulcer: three-day antibiotic eradication regimen

Autor:	C Bentivegna, Rosanna Cipolla, F. Catalano, Roberto Catanzaro, A. Brogna, G. Branciforte
Rok vydání:	2000
Předmět:	medicine.medical_specialty Hepatology biology business.industry Gastroenterology Amoxicillin Helicobacter pylori Pharmacology biology.organism_classification Ranitidine Regimen Metronidazole Internal medicine Clarithromycin Medicine Pharmacology (medical) business Omeprazole medicine.drug Antibacterial agent
Zdroj:	Alimentary Pharmacology & Therapeutics. 14:1329-1334
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2000.00839.x
Popis:	Background: The most widely used treatments for ulcer healing and Helicobacter pylori eradication consist of a 1–2 week regimen of a proton pump inhibitor plus two or three antimicrobials. Aims: To evaluate the efficacy, safety, cost, and tolerance of a three-day regimen with three antibiotics vs. a 10-day treatment with a proton pump inhibitor or vs. a ranitidine bismuth citrate triple therapy. Methods: Two hundred and twenty-one patients with endoscopically-proven H. pylori-positive duodenal ulcers were recruited to the study. Recruited patients were assigned to one of the following four regimens: (I) omeprazole 40 mg o.m. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (OAC: 55 patients); (ii) omeprazole 40 mg o.m. on days 1–5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3–5 (OACM: 56 patients); (iii) ranitidine bismuth citrate 400 mg b.d. plus amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. for 10 days (RAC: 54 patients); (iv) ranitidine bismuth citrate 400 mg b.d. on days 1–5, plus amoxycillin 1 g b.d., clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. on days 3–5 (RACM: 56 patients). Fisher’s exact test was used to compare data regarding healing and eradication in the four groups. Results: The intention-to-treat eradication and ulcer healing rates for the RACM regimen were 95% and 98%, respectively. Statistically significant differences were observed, relating to the eradication and healing of ulcers, between RACM and either the RAC or OAC regimens. Conclusion: The three-day antibiotic therapy with amoxycillin, clarithromycin and metronidazole in addition to ranitidine bismuth citrate is a very effective anti-H. pylori regimen.
Databáze:	OpenAIRE
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