| Autor: |
Tomer Rotstein, Emily R Ko, Gregory D. Sempowski, Chen Yu, Thomas N. Denny, Ephraim L. Tsalik, Rui Xi, Hong Chung, Daniel R. Saban, Sejiro Littleton, Shengli Ding, Rose Mathew, Micah T. McClain, Thomas W. Burke, Xiling Shen, Grecia rivera Palomino, Elizabeth Petzold, Christopher W. Woods, Joan Kalnitsky, Nicholas S. Giroux |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.12.01.407148 |
| Popis: |
Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral blood mononuclear cells from confirmed COVID-19 inpatients and outpatients, uninfected close contacts, and healthy controls for 36-color flow cytometry and single cell RNA-sequencing. Our results revealed a pronounced reduction of circulating mucosal associated invariant T (MAIT) cells in infected females. Integration of published COVID-19 airway tissue datasets implicate that this reduction represented a major wave of MAIT cell extravasation during early infection in females. Moreover, female MAIT cells possessed an immunologically active gene signature, whereas male counterparts were pro-apoptotic. Collectively, our findings uncover a female-specific protective MAIT profile, potentially shedding light on reduced COVID-19 susceptibility in females. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
