Slow Synaptic Responses in Neuronal Tumor Cells: Dual Regulation of ADP-Ribosyl Cyclase and Inhibition of M-Current by Muscarinic Receptor Stimulation
| Autor: | Haruhiro Higashida, Minako Hashii, Megumi Taketo, Shigeru Yokoyama |
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| Rok vydání: | 2000 |
| Předmět: |
ADP-ribosyl Cyclase
medicine.medical_specialty Muscarinic acetylcholine receptor M2 Muscarinic acetylcholine receptor M1 Cyclase Cell biology Adenylyl cyclase chemistry.chemical_compound Endocrinology chemistry Internal medicine Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor M5 Muscarinic acetylcholine receptor M4 medicine |
| Zdroj: | Slow Synaptic Responses and Modulation ISBN: 9784431669753 |
| DOI: | 10.1007/978-4-431-66973-9_4 |
| Popis: | Muscarinic acetylcholine receptors (mAChRs) utilize the direct signaling pathway to ADP-ribosyl cyclase via G proteins within cell membranes to produce cyclic ADP-ribose (cADPR) from s-NAD+. This signal cascade is analogous to the previously established transduction pathways from mAChRs to adenylyl cyclase and phospholipase Cs. Together with cytosolic Ca2+, cADPR functions to release Ca2+ through ryanodine receptors. This cADPR-dependent and mAChR-controlled increase in cytosolic Ca2+ concentrations may induce various cellular responses. |
| Databáze: | OpenAIRE |
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