Abstract 042: Cd74-dysregulation of Macrophage-trophoblastic Interactions in the Preeclamptic Placenta
| Autor: | Lukasz Przybyl, Nadine Haase, Michaela Golic, Julianna Rugor, Maria E Solano, Petra C Arck, Martin Gauster, Berthold Huppertz, Jürgen Bernhagen, Richard Bucala, Friedrich C Luft, Anne C Staff, Dominik N Mueller, Ralf Dechend, Florian Herse |
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| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Hypertension. 66 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/hyp.66.suppl_1.042 |
| Popis: | Objectives: Preeclamptic pregnancies feature placental anomalies. Villous trophoblast differentiation during placental development is regulated by feto-placental macrophages and disturbance of this well-balanced regulation can lead to pathological pregnancies. We hypothesized that Cluster of differentiation 74 (CD74) dysregulation of placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia. Methods and Results: We performed microarray analysis of placental tissue. CD74 was one of the most down-regulated (-2.5 fold) genes in placentas from preeclamptic women. We confirmed this finding in early onset ( Conclusions: We found that CD74 downregulation in placental macrophages is present in preeclampsia. CD74 downregulation led to altered macrophage activation towards a pro-inflammatory signature, a disturbed crosstalk with trophoblasts and an abnormal placental morphology. |
| Databáze: | OpenAIRE |
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