Greater Accuracy in Concussion Diagnosis in Collegiate Athletes through the use of Blood Brain Biomarkers
| Autor: | Steve Rowson, Sundeep Dhanju, Anand Tripathi, Mark A. Rogers, Eric E. Smith, Mike Goforth, Per Gunnar Brolinson |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
education.field_of_study biology business.industry Traumatic brain injury Athletes Population Retrospective cohort study Emergency department Football medicine.disease biology.organism_classification Concussion Physical therapy medicine Biomarker (medicine) Neurology (clinical) business education |
| Zdroj: | Neurology. 93:S5.1-S5 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectiveThe primary aim is to document the cumulative neuropathologic burden of sport-related concussion via brain biomarkers (e.g., S100B and GFAP) in collegiate athletes at baseline, during the acute phase of a concussive injury, at return to play, and upon completion of collegiate athletic participation.BackgroundSport-related concussion is a major public health concern currently. Yet, the diagnosis is all done clinically, without a standardized objective measurement that could definitively implicate the presence of a concussion. Previous studies have shown blood brain biomarkers to be useful in determining the diagnosis of traumatic brain injury. Indeed, few studies have shown biomarkers that are highly sensitive and specific for detecting concussion in the general population and the FDA has approved such a biokit for public use. This biokit is used to determine if a brain CT scan is needed for an alert patient that presents to the emergency department following head trauma. However, much more work is needed to for concussion diagnosis in collegiate athletes.Design/MethodsA retrospective study is being conducted to analyze the blood biomarkers and head acceleration data collected from a pilot project. Four different groups are being used in this study: (1) nonimpact, (2) vigorous athletic controls (swimming, running, and baseball), (3) non- concussed football player (active controls), and (4) concussed football players.ResultsPreliminary results indicate significant differences in the means for the aforementioned groups (F = 3.85, df = 5.69 p = 0.0070, n = 74). Serum S100B levels are also significantly different for pre- and post-concussion groups (F = 4.51, p = 0.0405, df = 37).ConclusionsThere is a statistical difference in the blood biomarker levels in concussed versus non-concussed players. Current work is being undertaken to correlate head acceleration data to serum biomarker findings of concussion at baseline, post injury and completion of collegiate athletic participation to further study biomarker as a diagnostic tool in athletes. |
| Databáze: | OpenAIRE |
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